programmed cell death 28.494050 apoptotic process 27.495097 cellular macromolecule metabolic process 27.177581 macromolecule metabolic process 26.119163 cellular response to stress 25.304287 cell death 22.618518 death 22.103070 cellular metabolic process 21.696331 primary metabolic process 19.305215 metabolic process 18.572833 regulation of response to stress 17.097730 toll-like receptor 4 signaling pathway 16.611096 MyD88-independent toll-like receptor signaling pathway 16.611096 TRIF-dependent toll-like receptor signaling pathway 15.955084 Toll signaling pathway 15.955084 toll-like receptor 3 signaling pathway 15.955084 positive regulation of protein phosphorylation 15.731911 pattern recognition receptor signaling pathway 15.515883 toll-like receptor signaling pathway 15.515883 regulation of protein metabolic process 15.242475 positive regulation of protein kinase activity 14.897249 positive regulation of phosphorylation 14.314008 induction of apoptosis 14.060817 induction of programmed cell death 14.060817 positive regulation of phosphate metabolic process 13.871549 positive regulation of phosphorus metabolic process 13.871549 protein phosphorylation 13.774478 regulation of cellular protein metabolic process 13.732390 regulation of protein modification process 13.625767 phosphorylation 13.575301 negative regulation of gene expression 13.379936 chromatin organization 13.209880 positive regulation of kinase activity 12.951158 positive regulation of protein modification process 12.849793 positive regulation of transferase activity 12.739633 positive regulation of defense response 12.717180 cellular protein metabolic process 12.691230 MAPK cascade 12.665090 toll-like receptor 1 signaling pathway 12.612542 toll-like receptor 2 signaling pathway 12.612542 cellular process 12.587391 positive regulation of molecular function 12.461868 activation of innate immune response 12.322049 innate immune response-activating signal transduction 12.322049 negative regulation of RNA metabolic process 12.310416 negative regulation of transcription, DNA-dependent 12.310416 DNA metabolic process 12.281654 positive regulation of cellular protein metabolic process 12.193313 macromolecular complex subunit organization 12.161462 negative regulation of cellular macromolecule biosynthetic process 12.112968 cellular component organization 12.052922 activation of protein kinase activity 11.860192 cellular component organization or biogenesis 11.836189 negative regulation of nitrogen compound metabolic process 11.788155 negative regulation of nucleobase-containing compound metabolic process 11.788155 regulation of protein phosphorylation 11.694123 response to stress 11.613276 MyD88-dependent toll-like receptor signaling pathway 11.579125 positive regulation of innate immune response 11.565093 response to endoplasmic reticulum stress 11.460779 positive regulation of protein metabolic process 11.252639 negative regulation of macromolecule biosynthetic process 11.232156 stress-activated MAPK cascade 11.228639 stress-activated protein kinase signaling cascade 11.228639 cell cycle checkpoint 11.087818 positive regulation of response to stimulus 11.084541 negative regulation of macromolecule metabolic process 11.045806 negative regulation of cellular biosynthetic process 11.037286 protein metabolic process 11.028215 macromolecular complex assembly 10.968487 chromosome organization 10.966545 interspecies interaction between organisms 10.918250 cellular component organization at cellular level 10.917796 cellular protein modification process 10.761379 protein modification process 10.761379 cellular component organization or biogenesis at cellular level 10.760154 response to gamma radiation 10.734644 positive regulation of catalytic activity 10.716223 regulation of interphase of mitotic cell cycle 10.710836 negative regulation of biosynthetic process 10.679439 response to UV 10.573815 negative regulation of metabolic process 10.444934 positive regulation of protein serine/threonine kinase activity 10.259895 phosphate-containing compound metabolic process 10.230927 phosphorus metabolic process 10.230927 regulation of intracellular protein kinase cascade 10.182020 organelle organization 10.134923 regulation of innate immune response 10.103462 nucleosome assembly 10.069077 regulation of phosphorylation 9.988838 macromolecule modification 9.922827 regulation of phosphate metabolic process 9.921767 regulation of phosphorus metabolic process 9.921767 negative regulation of transcription from RNA polymerase II promoter 9.906429 regulation of defense response 9.767935 regulation of protein kinase activity 9.750479 cellular component assembly 9.664870 regulation of cell cycle process 9.622902 response to DNA damage stimulus 9.555945 intracellular protein kinase cascade 9.543272 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 9.517135 regulation of transferase activity 9.494136 nucleic acid metabolic process 9.445892 protein-DNA complex assembly 9.397234 regulation of G1/S transition of mitotic cell cycle 9.378117 immune response-activating signal transduction 9.369562 chromatin assembly 9.355728 negative regulation of cellular metabolic process 9.318898 cellular response to unfolded protein 9.312356 endoplasmic reticulum unfolded protein response 9.312356 regulation of cell cycle arrest 9.311065 cytoplasmic pattern recognition receptor signaling pathway 9.277611 activation of MAPK activity 9.273391 positive regulation of immune response 9.268976 regulation of cell death 9.213037 induction of apoptosis by intracellular signals 9.123262 fibroblast growth factor receptor signaling pathway 9.069059 nucleosome organization 9.002442 regulation of programmed cell death 8.975110 positive regulation of MAP kinase activity 8.972294 mitotic cell cycle checkpoint 8.961431 chromatin assembly or disassembly 8.891039 positive regulation of signaling 8.815325 regulation of organelle organization 8.647007 regulation of cell cycle 8.560902 cellular component biogenesis 8.556924 regulation of apoptotic process 8.531173 regulation of kinase activity 8.502501 cell-type specific apoptotic process 8.481898 response to abiotic stimulus 8.471942 cell cycle arrest 8.439115 activation of immune response 8.432246 ER-nucleus signaling pathway 8.411523 positive regulation of cell communication 8.396487 positive regulation of signal transduction 8.392651 cellular response to topologically incorrect protein 8.330306 nucleobase-containing compound metabolic process 8.326782 negative regulation of cell cycle 8.303709 regulation of molecular function 8.267609 nitrogen compound metabolic process 8.221749 positive regulation of intracellular protein kinase cascade 8.215492 protein-DNA complex subunit organization 8.195946 positive regulation of apoptotic process 8.121972 positive regulation of cell death 8.121972 positive regulation of programmed cell death 8.121972 DNA damage checkpoint 8.041044 DNA integrity checkpoint 8.041044 cellular nitrogen compound metabolic process 7.955418 G1/S transition checkpoint 7.955318 mitotic cell cycle G1/S transition checkpoint 7.955318 positive regulation of hydrolase activity 7.915477 regulation of immune system process 7.888835 cellular response to fibroblast growth factor stimulus 7.883396 response to fibroblast growth factor stimulus 7.883396 immune response-regulating signaling pathway 7.775764 activation of MAPKK activity 7.688321 DNA packaging 7.637396 regulation of signaling 7.637003 regulation of MAP kinase activity 7.560608 histone modification 7.453328 positive regulation of peptidase activity 7.439822 nerve growth factor receptor signaling pathway 7.431663 signal transduction in response to DNA damage 7.411598 cell cycle process 7.321140 negative regulation of biological process 7.307421 positive regulation of cysteine-type endopeptidase activity 7.286997 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.286997 positive regulation of endopeptidase activity 7.286997 DNA conformation change 7.253798 cellular macromolecular complex subunit organization 7.217103 regulation of type I interferon production 7.205842 regulation of catalytic activity 7.186951 regulation of mitotic cell cycle 7.111793 cellular protein catabolic process 6.967752 proteolysis involved in cellular protein catabolic process 6.967752 intracellular signal transduction 6.961703 cellular response to radiation 6.948496 regulation of signal transduction 6.892395 regulation of cysteine-type endopeptidase activity 6.867916 regulation of cysteine-type endopeptidase activity involved in apoptotic process 6.867916 positive regulation of immune system process 6.855023 proteasomal protein catabolic process 6.851866 proteasomal ubiquitin-dependent protein catabolic process 6.851866 negative regulation of growth 6.799361 interphase 6.784478 interphase of mitotic cell cycle 6.784478 response to decreased oxygen levels 6.758292 response to hypoxia 6.758292 G1/S transition of mitotic cell cycle 6.692726 multi-organism process 6.684983 covalent chromatin modification 6.679158 regulation of cell communication 6.677910 positive regulation of sequence-specific DNA binding transcription factor activity 6.558703 positive regulation of NF-kappaB transcription factor activity 6.558609 regulation of cytokine production 6.557561 JNK cascade 6.556900 response to light stimulus 6.547590 viral reproductive process 6.539339 cell cycle 6.522369 response to ionizing radiation 6.498722 cellular macromolecular complex assembly 6.470361 cellular response to abiotic stimulus 6.435078 release of cytochrome c from mitochondria 6.423863 response to oxygen levels 6.393073 regulation of cellular response to stress 6.324597 DNA damage response, signal transduction by p53 class mediator 6.274140 signal transduction by p53 class mediator 6.274140 negative regulation of cellular process 6.233754 regulation of I-kappaB kinase/NF-kappaB cascade 6.168703 positive regulation of protein transport 6.159508 mitotic cell cycle G1/S transition DNA damage checkpoint 6.146597 modification-dependent macromolecule catabolic process 6.115482 modification-dependent protein catabolic process 6.115482 regulation of peptidase activity 6.113605 cellular response to chemical stimulus 6.106120 nucleotide-binding oligomerization domain containing signaling pathway 6.102677 immune system process 6.100939 regulation of chromosome organization 6.095663 regulation of hydrolase activity 6.086018 regulation of stress-activated MAPK cascade 6.071404 regulation of stress-activated protein kinase signaling cascade 6.071404 neuron apoptotic process 6.046730 neuron death 6.046730 regulation of apoptotic signaling pathway 5.945643 regulation of protein serine/threonine kinase activity 5.936282 protein catabolic process 5.924906 cellular macromolecule catabolic process 5.893608 response to radiation 5.885898 regulation of endopeptidase activity 5.874640 chromatin modification 5.833495 DNA damage response, signal transduction resulting in induction of apoptosis 5.823397 regulation of sequence-specific DNA binding transcription factor activity 5.759459 regulation of DNA metabolic process 5.726099 regulation of immune response 5.717367 cellular response to organic substance 5.701231 response to growth factor stimulus 5.650516 macromolecule catabolic process 5.503069 regulation of MAPK cascade 5.492591 positive regulation of cytokine production 5.479351 activation of cysteine-type endopeptidase activity 5.471706 activation of cysteine-type endopeptidase activity involved in apoptotic process 5.471706 cellular response to growth factor stimulus 5.467927 regulation of response to stimulus 5.454771 myoblast differentiation 5.417214 apoptotic mitochondrial changes 5.409267 cellular response to ionizing radiation 5.340140 ubiquitin-dependent protein catabolic process 5.339637 negative regulation of cell growth 5.314481 regulation of cellular component organization 5.292973 regulation of ERK1 and ERK2 cascade 5.286265 antigen receptor-mediated signaling pathway 5.280015 positive regulation of apoptotic signaling pathway 5.227837 negative regulation of mitotic cell cycle 5.202215 regulation of transport 5.188153 SRP-dependent cotranslational protein targeting to membrane 5.155631 cotranslational protein targeting to membrane 5.155631 establishment of protein localization in endoplasmic reticulum 5.155631 protein localization in endoplasmic reticulum 5.155631 protein targeting to ER 5.155631 proteolysis 5.104786 regulation of multicellular organismal process 5.101905 regulation of biological quality 5.092953 ERBB signaling pathway 5.008268 epidermal growth factor receptor signaling pathway 5.008268 anti-apoptosis 4.990060 negative regulation of molecular function 4.981094 mitochondrion organization 4.962087 viral infectious cycle 4.934555 signal transduction involved in DNA damage checkpoint 4.928690 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 4.928690 signal transduction involved in DNA integrity checkpoint 4.928690 signal transduction involved in G1/S transition checkpoint 4.928690 signal transduction involved in cell cycle checkpoint 4.928690 signal transduction involved in mitotic cell cycle G1/S checkpoint 4.928690 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint 4.928690 signal transduction involved in mitotic cell cycle checkpoint 4.928690 transmembrane receptor protein tyrosine kinase signaling pathway 4.854174 regulation of cell growth 4.847099 regulation of histone modification 4.842976 regulation of cytokine biosynthetic process 4.832841 positive regulation of I-kappaB kinase/NF-kappaB cascade 4.812185 regulation of protein localization 4.781620 cellular component assembly at cellular level 4.723790 apoptotic signaling pathway 4.708755 positive regulation of intracellular protein transport 4.705435 positive regulation of intracellular transport 4.705435 negative regulation of protein metabolic process 4.693880 response to organic substance 4.686774 negative regulation of type I interferon production 4.655891 positive regulation of multicellular organismal process 4.632825 negative regulation of cell death 4.628724 mitotic cell cycle 4.618010 cellular macromolecule localization 4.566966 cellular protein localization 4.566966 regulation of homeostatic process 4.562157 regulation of cellular localization 4.545825 immune response-activating cell surface receptor signaling pathway 4.509411 regulation of intracellular transport 4.492040 response to unfolded protein 4.440297 response to hydrogen peroxide 4.431941 response to oxidative stress 4.426956 protein targeting 4.403619 response to chemical stimulus 4.386995 response to insulin stimulus 4.350374 regulation of protein catabolic process 4.350239 positive regulation of protein secretion 4.334154 response to lipopolysaccharide 4.319872 negative regulation of cell cycle process 4.296248 protein complex subunit organization 4.286138 regulation of wound healing 4.286138 positive regulation of ERK1 and ERK2 cascade 4.196429 regulation of establishment of protein localization 4.191837 induction of apoptosis by extracellular signals 4.182652 regulation of transcription involved in G1/S phase of mitotic cell cycle 4.163141 negative regulation of apoptotic process 4.159783 G1 phase 4.147022 G1 phase of mitotic cell cycle 4.147022 positive regulation of type I interferon production 4.146728 protein targeting to membrane 4.142306 viral genome expression 4.138894 viral transcription 4.138894 regulation of peptidyl-tyrosine phosphorylation 4.137505 regulation of nucleocytoplasmic transport 4.103963 protein processing 4.095407 response to topologically incorrect protein 4.069909 lipopolysaccharide-mediated signaling pathway 4.065367 cellular response to starvation 4.054011 immune system development 4.046743 hemopoietic or lymphoid organ development 4.029584 response to bacterium 4.019314 response to external stimulus 3.989130 positive regulation of nucleocytoplasmic transport 3.987616 cellular response to tumor necrosis factor 3.976504 negative regulation of cytokine production 3.976071 intracellular transport 3.965855 cellular response to drug 3.956326 regulation of localization 3.929939 response to reactive oxygen species 3.920318 regulation of DNA replication 3.907036 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis 3.893977 signal transduction by p53 class mediator resulting in induction of apoptosis 3.893977 response to molecule of bacterial origin 3.875251 negative regulation of programmed cell death 3.843737 enzyme linked receptor protein signaling pathway 3.836902 T cell receptor signaling pathway 3.815856 positive regulation of cell cycle process 3.814084 intracellular protein transport 3.810330 regulation of neuron apoptotic process 3.801562 regulation of neuron death 3.801562 response to exogenous dsRNA 3.794810 negative regulation of response to stimulus 3.781723 viral reproduction 3.769005 cellular response to stimulus 3.758754 positive regulation of cell cycle arrest 3.754715 protein import 3.737736 regulation of intracellular protein transport 3.736386 homeostasis of number of cells 3.728510 activation of pro-apoptotic gene products 3.677368 regulation of cell differentiation 3.664629 regulation of JNK cascade 3.661656 maintenance of protein location 3.658769 maintenance of protein location in cell 3.658769 negative regulation of cellular component organization 3.612579 response to acid 3.583461 epithelial cell proliferation 3.567058 regulation of growth 3.553846 protein localization to organelle 3.521875 regulation of myeloid cell differentiation 3.494557 positive regulation of organelle organization 3.487828 cellular response to biotic stimulus 3.466529 regulation of kidney development 3.438726 mitochondrial membrane organization 3.436346 activation of signaling protein activity involved in unfolded protein response 3.410344 regulation of canonical Wnt receptor signaling pathway 3.387567 maintenance of location 3.386378 negative regulation of protein modification process 3.380885 regulation of body fluid levels 3.350162 proximal/distal pattern formation 3.346467 cell activation 3.337732 cellular membrane organization 3.335029 membrane organization 3.335029 protein complex assembly 3.329370 protein complex biogenesis 3.329370 DNA repair 3.319615 regulation of protein import into nucleus 3.314550 regulation of protein localization to nucleus 3.314550 immune response-regulating cell surface receptor signaling pathway 3.312039 regulation of protein transport 3.308450 response to dsRNA 3.278086 ER-associated protein catabolic process 3.264654 regulation of response to external stimulus 3.262663 response to drug 3.259521 regulation of neuronal synaptic plasticity 3.249405 negative regulation of NF-kappaB transcription factor activity 3.247396 negative regulation of catabolic process 3.247396 regulation of peptidyl-serine phosphorylation 3.247396 regulation of tyrosine phosphorylation of STAT protein 3.247396 transforming growth factor beta receptor signaling pathway 3.236031 hemopoiesis 3.235251 leukocyte migration 3.232622 regulation of binding 3.229036 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 3.197080 negative regulation of cellular protein metabolic process 3.178853 establishment of localization 3.175679 regulation of epithelial cell differentiation 3.168530 response to tumor necrosis factor 3.163096 positive regulation of protein oligomerization 3.156605 regulation of protein oligomerization 3.156605 regulation of smooth muscle cell differentiation 3.155816 digestive tract development 3.145724 maintenance of location in cell 3.143421 negative regulation of organelle organization 3.143421 protein homooligomerization 3.143421 axon guidance 3.141219 G2/M transition checkpoint 3.135489 negative regulation of protein catabolic process 3.135489 peptidyl-serine modification 3.135489 peptidyl-serine phosphorylation 3.135489 positive regulation of Wnt receptor signaling pathway 3.135489 positive regulation of cytokine secretion 3.135489 positive regulation of peptidyl-serine phosphorylation 3.135489 positive regulation of striated muscle cell differentiation 3.135489 receptor metabolic process 3.135489 regulation of protein kinase B signaling cascade 3.135489 myeloid cell differentiation 3.122308 nuclear transport 3.107930 nucleocytoplasmic transport 3.107930 response to starvation 3.096162 monocyte differentiation 3.092217 protein modification by small protein conjugation or removal 3.084246 Notch signaling pathway 3.080075 positive regulation of protein import into nucleus 3.055736 positive regulation of transmembrane transport 3.055736 leukocyte differentiation 3.043780 response to biotic stimulus 3.038989 regulation of extrinsic apoptotic signaling pathway 3.032943 regulation of lipid storage 3.012617