protein metabolic process 12.450077 protein localization in endoplasmic reticulum 11.489516 macromolecule catabolic process 10.617659 mRNA metabolic process 10.602519 cellular protein metabolic process 10.522911 cellular macromolecule catabolic process 10.416013 proteasomal protein catabolic process 10.194107 proteasomal ubiquitin-dependent protein catabolic process 10.194107 proteolysis 9.754182 ubiquitin-dependent protein catabolic process 9.298214 cellular protein catabolic process 8.883442 proteolysis involved in cellular protein catabolic process 8.883442 modification-dependent macromolecule catabolic process 8.829857 modification-dependent protein catabolic process 8.829857 ER-associated protein catabolic process 8.729040 RNA splicing, via transesterification reactions 8.547780 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 8.547780 nuclear mRNA splicing, via spliceosome 8.547780 macromolecule metabolic process 8.434719 protein catabolic process 8.077491 SRP-dependent cotranslational protein targeting to membrane 7.707316 cotranslational protein targeting to membrane 7.707316 establishment of protein localization in endoplasmic reticulum 7.707316 protein targeting to ER 7.707316 catabolic process 7.653250 cellular macromolecule metabolic process 7.288839 metabolic process 7.278088 primary metabolic process 7.197648 cellular catabolic process 7.189013 induction of apoptosis 7.018842 induction of programmed cell death 7.018842 protein targeting to membrane 6.851697 nuclear-transcribed mRNA catabolic process 6.748197 RNA splicing 6.543100 cellular metabolic process 6.389202 protein localization to organelle 6.082468 activation of MAPK activity 5.880045 mRNA catabolic process 5.869793 establishment of protein localization to organelle 5.855976 peptide metabolic process 5.487664 cell death 5.353471 death 5.254860 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 5.245959 nucleosome assembly 5.182533 positive regulation of protein serine/threonine kinase activity 5.129113 DNA metabolic process 5.053302 positive regulation of MAP kinase activity 5.025421 RNA processing 4.972597 JNK cascade 4.952889 intracellular protein transport 4.897133 protein targeting 4.873113 induction of apoptosis by extracellular signals 4.732550 nucleosome organization 4.328408 protein-DNA complex assembly 4.274427 cellular macromolecular complex subunit organization 4.260820 regulation of MAP kinase activity 4.185617 chromatin assembly 4.159730 activation of protein kinase activity 3.945733 cellular protein modification process 3.839022 protein modification process 3.839022 mRNA processing 3.832747 phosphate-containing compound metabolic process 3.787758 phosphorus metabolic process 3.787758 RNA catabolic process 3.775362 translation 3.608812 intracellular transport 3.603272 phosphorylation 3.476261 protein-DNA complex subunit organization 3.450492 macromolecule modification 3.394180 macromolecular complex subunit organization 3.388716 nucleotide-binding oligomerization domain containing signaling pathway 3.358829 regulation of intracellular protein kinase cascade 3.306950 DNA packaging 3.225200 cellular response to stress 3.169294 induction of apoptosis via death domain receptors 3.052955 regulation of protein serine/threonine kinase activity 3.050662