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Covalent modifications to both DNA and histone proteins allow chromatin to act as a dynamic information hub that integrates diverse biochemical stimuli to regulation genomic DNA access and ultimately establish and maintain cellular identity. 

Aberrant chromatin regulation, as a consequence of mutation or abnormal signaling is associated with many diseases, especially cancer. The identification of oncogenic mutations has led to the emerging view of “driver mutations” in chromatin regulators underlying many cancers.

We aim to define how changes in chromatin structures aids in the establishment and maintenance of gene expression programs involved in normal development and tumorigenesis. 

The Lewis Lab, Wisconsin Institute for Discovery, Madison, WI 53715

©2019 Board of Regents of the University of Wisconsin System

Lewis Laboratory

@Wisconsin Institute for Discovery